Why is cellular recycling so crucial for health?
Our bodies are made of trillions of cells functioning in perfect harmony with each other to form healthy tissues and cell bodies. If cells start to accumulate waste such as dysfunctional cell organelles, proteins, cell debris, or excess of harmful substances such as reactive oxygen species, carcinogens, or pathogens, their function starts to decline. Cells have a recycling system called autophagy for recycling this waste for further use1. Unfortunately, the autophagy function may decline and impair for several reasons, including aging and several disease states. The decline in the autophagy response is leading to dysfunction and death of the cells leading to tissue damage.
How the autophagy function may be improved in human cells
Recently autophagy has become a key interest for scientists who want to improve cellular function. The main reason is that autophagy is linked to almost all bodily functions such as energy metabolism, immune system, cardiovascular-, eye-, and brain health2. There are ways to increase autophagy, and the most known is restricting calorie intake. Some substances induce autophagy. For example, natural anthocyanins from bilberry extract have been shown promising effects in autophagy induction in in-vivo studies with rats and fruit flies2,4. In addition, the Chaga mushroom is shown to have potential in autophagy induction in cell line studies5.
Eevia Health products supporting cellular recycling
We offer a few products that may support the healthy functioning of cells:
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1. Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011
2. Lu G, Wang Y, Shi Y, Zhang Z, Huang C, He W, Wang C, Shen HM. Autophagy in health and disease: From molecular mechanisms to therapeutic target. MedComm (2020).
3. Li J, Zhao R, Zhao H, Chen G, Jiang Y, Lyu X, Wu T. Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK-mTOR Signaling Pathway in Aged Female Rats. J Agric Food Chem. 2019 Jul 17;67(28):7832-7843. doi: 10.1021/acs.jafc.9b02567. Epub 2019 Jul 9. PMID: 31242723.
4. Zhang G, Dai X. Antiaging effect of anthocyanin extracts from bilberry on natural or UV-treated male Drosophila melanogaster. Curr Res Food Sci. 2022
5. Lee MG, Kwon YS, Nam KS, Kim SY, Hwang IH, Kim S, Jang H. Chaga mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells. J Ethnopharmacol. 2021